Much of Lopez's comedy is based on his experiences in childhood, and that of the Mexican-American community in general. He has released four albums of recorded stand-up comedy shows, the first of which was Alien Nation in 1996, as well as Right Now Right Now and Team Leader, which was nominated for a 2004 Grammy Award for Best Comedy Album.[1] He released El Mas Chingon in September 2006. On television Lopez has appeared on The Latin Kings of Comedy, where he was a guest star along with other top Latino stand-up comedians. His first stand-up comedy special, George Lopez Why You Crying? premiered on Showtime. His second special, America's Mexican, was broadcast live on HBO on February 24, 2007. George Lopez is also starring the 2008 film Beverly Hills Chihuahua.
Lopez had made his mark as a comedian, performing at several clubs around the country and making appearances on television shows and comedy specials by the late 1980s. In the 1990s, Lopez made the transition to films with comedies such as Ski Patrol (1990) and Fatal Instinct (1993). Despite his growing television career, Lopez continued to perform his stand-up comedy and recorded several comedy albums.
Lopez was a cast member and commentator for HBO’s hit sports show Inside the NFL for the 2003-2004 football season. He is a two-time host of the Latin Grammy Awards and a co-host of the Emmy Awards. He recently starred in the ABC Wonderful World of Disney Christmas film Naughty or Nice. Lopez also starred in the Robert Rodríguez-directed film The Adventures of Shark Boy & Lava Girl which opened in June 2005.
Lopez guest starred as the Mayor of Reno, Nevada in the fifth season of Reno 911! in 2008. In January 2009, Lopez appeared in the We Are One: The Obama Inaugural Celebration at the Lincoln Memorial.